Furthermore, the expression of PD-1, CTLA-4, TIM-3, V-domain Ig suppressor of T cell activation (VISTA), and lymphocyte activating 3 (LAG3) positively correlates with HVEM, suggesting its potential role in immune suppression within the GBM microenvironment [94, 95]. The gene discussed is PDCD1; the disease is glioblastoma.