It is the resident TAMs of the CNS and secretes immunosuppressive factors like interleukin-10 (IL-10) and transforming growth factor-β (TGF-β) or other anti-tumor stimulating factors like IL-12 and tumor necrosis factor-α (TNF-α) based on the “heat” or “cold” status of the TME [14]. The gene discussed is TNF; the disease is neoplasm.