For example, Mao et al. [70] found that metabolic stress in obese patients induces endothelial cell inflammation, and the cGAS-STING pathway is active in PA-induced aortic endothelium, whereas in vivo experiments have shown that STING-deficient (STINGgt/gt) mice prevent high-fat diet-induced vascular inflammation, insulin resistance, and glucose intolerance. This evidence concerns the gene STING1 and Insulin resistance.