IL21R and hepatocellular carcinoma: Interestingly, most of these patients expressed high IL-21R (17/21 = 81%), and most of the patients with high IL-21R expression exhibited moderate to severe steatosis (15/17 = 88%), whereas most of the patients with low IL-21R expression displayed mild steatosis (3/4 = 75%, Fig. 1D and Table S4), suggesting that IL-21R might play an important role in MASH-related HCC.