In the present study, we revealed that the IL-21R-STAT1-c-Jun/c-Fos-IgA regulatory pathway was activated during MASH-driven hepatocarcinogenesis, leading to the induction of immunosuppressive IgA+ B cells, and thereby inhibited CTL activation and eventually facilitated MASH-driven HCC in vivo. The gene discussed is CD79A; the disease is hepatocellular carcinoma.