IL21R and hepatocellular carcinoma: Here, we presented the following evidences: (i) Assessment of the levels of IL-21R by using IHC staining revealed that elevated IL21R expression was correlated with advanced stage of HCC and poor survival in our cohort (n = 69), and the conclusion was validated in two additional independent cohorts (n = 80 and 365, respectively) according to the TCGA database.