Comparing NN-NF to NN-HN, we observed common trends in the upregulation of ANGPTL4, DDIT4, STC2, ALDOC, BHLHE40, NDRG1, PLAUR, and CDKN1A. These genes have been previously characterized as biomarkers for CRC and have been directly correlated with increased aggressiveness of CRC. The gene discussed is STC2; the disease is colorectal carcinoma.