Under normoxia, we found that infection with Fnn modulated the expression of the following genes: CBX7, LINC010189, SEMA6B, MYO1C, CARD8, ELN, and TMOD3. In hypoxia, these include WDYHV1, TSPAN19, INFGR2, CLUAP1, and SND1. These genes have been previously found to adversely impact CRC progression. This evidence concerns the gene CARD8 and infection.