CD8A and central nervous system cancer: Specifically, our analysis revealed that CD47 was prominently expressed on CD8 + exhausted T cells (CD8 + Tex), exhibiting significantly higher expression levels compared to other CD8 + T cell subsets in AML, BRCA, CHOL, CLL, CRC, ESCA, Glioma, HNSC, KICH, LIHC, MCC, MM, NHL, NSCLC, OS, OV, PRAD, SCC, SCLC, SKCM, THCA, and UVM (Fig. 6c).