Specifically, our analysis revealed that CD47 was prominently expressed on CD8 + exhausted T cells (CD8 + Tex), exhibiting significantly higher expression levels compared to other CD8 + T cell subsets in AML, BRCA, CHOL, CLL, CRC, ESCA, Glioma, HNSC, KICH, LIHC, MCC, MM, NHL, NSCLC, OS, OV, PRAD, SCC, SCLC, SKCM, THCA, and UVM (Fig. 6c). The gene discussed is CD47; the disease is central nervous system cancer.