GPX4 and neoplasm: We previously showed that TRCs were insensitive to System Xc−/GSH/GPX4 blocking (Fig. 1e,f,h,i,k, Extended Data Fig. 1h,i,l and Supplementary Fig. 1f,g), and the expression of key genes (SLC7A11 and GPX4) and intracellular GSH levels showed no significant difference between bulk tumor cells and TRCs (Extended Data Fig. 2a,b).