By quantitative mass spectrometry analysis with anti-ACSL4 immunoprecipitates from lysates of HONE1 bulk tumor cells or TRCs, we identified kinases PCK2, PKM2 and PFKP, as well as phosphatase PPM1G, from the top 250 most enriched proteins in the precipitates. The gene discussed is PCK2; the disease is neoplasm.