Again, previous research has established the CACNA1C-rs1006737 A allele as a risk factor for SZ through GWAS and meta-analytic approaches (Liu et al. 2020; Trubetskoy et al. 2022) and has demonstrated its detrimental effect on longitudinal GAF scores and recovery after psychotic episodes (Heilbronner et al. 2015). This evidence concerns the gene CACNA1C and Psychotic episodes.