TYR and melanoma: Further, we detected signature melanosomal markers TYR, DCT, GPR143, and GPNMB (Dror et al, 2016; Raposo and Marks, 2007; Giordano et al, 2009; Hoashi et al, 2010) in the melanosomes derived from melanoma cells, fibroblasts and keratinocytes (Fig. EV2I).