CD4 and neoplasm: Next, we investigated tumor immune recognition and found significantly more infiltration of CD4+ T cells, CD8+ T cells, and CD11b+ myeloid cells in the tumors of the mice co-grafted with macrophages incubated with keratinocyte-derived melanosomes than in controls grafted with B16-F10 cells, whereas all other treatment groups were similar to the control (Fig. 3I–K).