Cells that co-stained with CD68 and GPNMB were scattered in the compound nevi, whereas in the in situ and vertical melanomas and lymph-metastasized melanoma, these co-stained cells were located internal to the melanoma cells or within the tumor microenvironment (Figs. 1A,B and  EV1A). The gene discussed is GPNMB; the disease is neoplasm.