CD31 and Tie1 are implicated in the development of vascular integrity and tumor angiogenesis and Mtor, which encodes a component of the PI3K-AKT-mTOR pathway responsible for releasing VEGF, a crucial factor in tumor angiogenesis and is also known to transform tumor-associated macrophages (Kim et al, 2013; La Porta et al, 2018; Pieniazek et al, 2018; Karar and Maity, 2011; Chen et al, 2012). Here, TIE1 is linked to neoplasm.