Furthermore, previous investigations seem to support the idea that unlike VEGF and ANGPT-2, the expression level of ANGPT-1 is significantly lower in colon cancer cells compared to normal colonic epithelium, and transfecting human colon carcinoma cell line with ANGPT-1 inhibited the tumor cell proliferation and growth11,12. Here, ANGPT1 is linked to malignant colon neoplasm.