Based on data retrieved by TCGA project, ANGPT-1 was significantly downregulated (P-value < 0.001) (Fig. 2A), while ANGPT-2 and VEGF-A were significantly upregulated in COAD and READ tissues compare to normal tissues (P-value < 0.001), respectively (Fig. 2B, C). Here, ANGPT2 is linked to reading.