Interestingly, we noticed a more significant increase in the level of the ‘do not eat me signal’ CD47 in tumour cell-secreted sEVs after treatment with aT-sEVs compared to those in tumour cell-secreted sEVs after treatment with IFN-γ (Fig. 5c and Supplementary Fig. 6f), suggesting that aT-sEVs might result in low clearance rate of tumour sEVs by macrophages. The gene discussed is IFNG; the disease is neoplasm.