IFNG and neoplasm: Differentially expressed proteins were subjected to Gene ontology (GO) enrichment analysis, finding out that the upregulated proteins in sEVs secreted by IFN-γ-stimulated tumour cells were enriched in nucleic acid processing and translation (Supplementary Fig. 6c), while treatment with aT-sEVs led to enhanced EV biogenesis and trafficking in tumour cells (Supplementary Fig. 6d).