TREM-1 (Triggering Receptor Expressed on Myeloid Cells 1) signaling was also activated in heat-stressed liver tissues and is implicated in liver inflammation and fibrosis by promoting hepatic inflammation, activating stellate cells, and serving as a master regulator of Kupffer cell activation and linked to inflammation, lipid accumulation, fibrosis, and tumor progression in liver-related diseases63. Here, TREM1 is linked to neoplasm.