Anticipated enhancements in the measurement and activation of gene products, such as Synaptogyrin 4 (Syngr4), Kelch-like protein 4 (Klhl4), Gpx6, Plet1, Adgre4, Pin1rt1, Fam187a, Lrrc63, Am166a, Klrb1f., Mir5618, Mir6915, Mir7663, Odf4, were followed by diminished measurements and inhibition of gene products, namely Protocadherin 12 (Pcdh12), Transmembrane protein 12 (Tmem12), Serpine3, Tmem72, Fam124b, Krtap5-5, Msmp, Mir7011, Mir7651, Abcg5, observed in the neurological disease network within the brain tissues exposed to heat stress (Fig. 5A). Here, SERPINE3 is linked to nervous system disorder.