ACP5 and hyperthyroidism: Nevertheless, decreased trabecular number (−36.8% vs. untreated, Cre-negative mice, Fig S5k) and augmented trabecular separation (+44.3% vs. untreated, Cre-negative mice, Fig. S5m) at th femur and upregulated serum levels of both P1NP (+60.5% vs. untreated, Cre-negative mice, Fig. S5q) and TRAP (+65.9% vs. untreated, Cre-negative mice, Fig. S5r) indicate an early stage of hyperthyroidism-driven bone loss in female hyperthyroid Cre-negative mice, but not mice lacking Bmpr1a in osteoprogenitors.