In bone tissue of Bmpr1afl/fl;Osx-Cre mice, Bmpr1a expression tended to decrease in mice with active Cre-recombinase (−59.4%, P = 0.07) (Fig. 4a) and Klf9 expression was upregulated by 78.4% with hyperthyroidism (Fig. 4b) as compared with Cre-negative, euthyroid mice. The gene discussed is SP7; the disease is hyperthyroidism.