ACP5 and hyperthyroidism: Bone turnover parameters P1NP and TRAP increased with hyperthyroidism in both Cre-negative and Cre-positive male and female mice, although changes in TRAP levels of euthyroid versus hyperthyroid Cre-positive mice did not reach statistical significance in the male (+31.7%, p = 0.056), but only female cohort (+82.3%) (Fig. 1j, k; Fig. S1l, m).