Although hyperthyroidism, a condition with high circulating concentrations of thyroid hormones 3,3 ́,5-triiodo-L-thyronine (T3) and L-thyroxine (T4), is an established risk factor for secondary osteoporosis, the molecular mechanisms for thyroid hormone excess driven bone loss still remain incompletely understood2. The gene discussed is TG; the disease is hyperthyroidism.