MAPT and Parkinson disease: Using whole-blood as the tissue of reference, 21 significant risk genes were identified (adjusted p value < 0.05, Supplementary Data 1) including LRRC37A, LRRC37A2, and DCAKD, which are located near the microtubule-associated protein tau (MAPT) region in which haplotypes associate with the modulation of risk of PD and phenotypic manifestations (Fig. 1a)14,15.