The FcγR-mediated phagocytosis (MTZ-AD vs. H2O-AD: IPA z-score = 0.63, p < 0.001; MTZ-WT vs. H2O-WT: IPA z-score = 1.34, p-value = 0.0067) and the CLEAR signaling pathways (MTZ-AD vs. H2O-AD: IPA z-score = 1.00, p < 0.001; MTZ-WT vs. H2O-WT: IPA z-score = 1.41, p-value = 0.029) were predicted to be activated by MTZ treatment, suggesting that microglia clearance of Aβ played a role in the lower plaque burden observed in 5xFAD mice. Here, FCGR2A is linked to Alzheimer disease.