We identified 5 homeostatic microglia DEGs, three genes (Gpr34, Sall1 and Tgfbr1) that were downregulated in AD mice treated with MTZ (DESeq’s Wald test, p = 0.0015, p = 0.011 and p = 0.00080, respectively) and two genes (Tmem119 and Glul) were upregulated (p = 0.017 and p = 0.0070, Fig. 4D). Here, TMEM119 is linked to Alzheimer disease.