The administration of Lactobacillus amylovorus KU4 improved HFD-induced obesity in mice through the promotion of the expression of brown markers, such as Ucp1 and peroxisome proliferator-activated receptor gamma coactivator-1 alpha (Pgc1α), as well as other thermogenic events, such as an increase in mitochondria in adipocytes [49]. Here, PPARGC1A is linked to obesity due to melanocortin 4 receptor deficiency.