Srebp2 activity has also been reported to be reduced in neurodegenerative diseases such as Alzheimer’s disease (Mohamed et al, 2018; Tang et al, 2023), and Srebp2 has been reported to play an important role in the supply of cholesterol required for myelination (Zhou et al, 2021). This evidence concerns the gene SREBF2 and early-onset autosomal dominant Alzheimer disease.