NICE guidelines recommend SGLT-2 inhibitors with metformin as second line oral antidiabetic treatment for people with T2DM and cardiovascular disease CVD), or at high risk of CVD; however, for the broader population with T2DM without these indications, these guidelines recommend sulfonylureas, DPP-4 inhibitors, or SGLT-2 inhibitors along with metformin. The gene discussed is SLC5A2; the disease is cardiovascular disorder.