SLC5A2 and ST Elevation Myocardial Infarction: In particular, the pharmacological action of SGLT-2 inhibitors—namely, reducing blood pressure and cardiac preload and after load through diuretic mechanisms,89 would imply protective effects on hospital admissions for heart failure and on kidney endpoints; however, this would not necessarily translate to immediate protective effects during an ST elevated myocardial infarction or acute rupture of a coronary plaque.