KEGG pathway involves pathways in cancer, cytokine‐cytokine receptor interaction, MAPK signaling pathway, and cell cycle etc. Reactome pathways were included in signal transduction, GPCR downstream signaling, Cell Cycle Checkpoint, and Regulation of Insulin‐like Growth Factor, etc. In addition, the WIKI pathway revealed in nuclear receptors meta‐pathway, IL‐18 signaling pathway, Adipogenesis, and Spinal cord injury, etc., represented in Figure 5A–C. The gene discussed is IL18; the disease is cancer.