Among these, three are most significant such as AURKB, TTK, and PLK1 andseveral researchers identified all of these genes have previously been recognized as oncogenes, possible biomarkers for diagnosing and prognosis of early stage BC such as AURKB,43 UBE2C,44 CDCA8,45 CDC45,46 KIF15,47 TTK48 and PLK1.49 The gene discussed is PLK1; the disease is breast cancer.