By conducting transcriptomic profiling of 36 MSI-H/dMMR gastrointestinal tumors to identify predictors of response to PD-1 blockade, Chida et al. found that vascular endothelial growth factor (VEGF-A) was significantly correlated with enriched pathways in nonresponders [109]. The gene discussed is PDCD1; the disease is digestive system neoplasm.