Thus, in the present study, we aimed to investigate the relationship between plasma miR-143 or miR-145 levels and the LV function, between plasma miR-143 or miR-145 levels and LV dilation, and between plasma miR-143 or miR-145 levels and the plasma BNP level, a well-known marker of heart failure, in patients with heart diseases. This evidence concerns the gene NPPB and heart disorder.