IL10 and ulcerative colitis: Chronic inflammation in ulcerative colitis contributes to the accumulation of high levels of MDSCs in the colon, and in turn, high levels of MDSCs produce higher levels of IL-10, but the function of IL-10 is altered in this environment IL-10 instead activates STAT3, which results in increased expression of two genes, DNMT1 and DNMT3b-, contributing to the silencing of a tumor suppressor (Ibrahim et al. 2018).