CXCL1 is a pro-angiogenic CXCL1 is a pro-angiogenic chemokine, and PGE2 can induce CXCL1 expression, increase MDSC infiltration in colitis-associated colorectal cancer mouse models, promote in vivo tumor growth and increase tumor micro vessel formation. This evidence concerns the gene CXCL1 and colorectal cancer.