CALR and autoimmune disease: According to the classification criteria for pSS, as an autoimmune disease, patients with pSS may fall into the following categories: positive ANA, anti-SSA or anti-SSB antibodies, and focal lymphocytic infiltrates in lip gland histopathology; only positive ANA, anti-SSA or anti-SSB antibodies, but no focal lymphocytic infiltrates in lip gland histopathology; only focal lymphocytic infiltrates in lip gland histopathology, without autoantibodies [10].