To determine whether elevated TGFβ signaling also contributes to elevated IOP and glaucoma associated with Gould syndrome,23,24,29 here we tested the effect of genetically reducing TGFβ receptor 2 (TGFBR2), the common receptor for all three TGFβ ligands,36 on glaucoma-relevant phenotypes in Col4a1 mutant mice. Here, TGFB1 is linked to COL4A1/A2-related disorder.