Interestingly, gliomas of the pedHGG_RTK1A/B/C subclass, which may account for approximately one-third in unselected pedHGG_H3-/IDH-wt cases35 and accounted for half in our control group,22 were virtually absent in our series as well as in another independent pediatric GC cohort published by Broniscer et al.12 This evidence concerns the gene IDH1 and glioma.