IDH1 and central nervous system cancer: Interestingly, gliomas of the pedHGG_RTK1A/B/C subclass, which may account for approximately one-third in unselected pedHGG_H3-/IDH-wt cases35 and accounted for half in our control group,22 were virtually absent in our series as well as in another independent pediatric GC cohort published by Broniscer et al.12