Within published hemispheric cohorts of pedHGG, the frequency of EGFR mutations was 11/326 (3.4%)25 and 2/86 (2.3%).26 Unselected pedHGG_H3-/IDH-wt tumors may show EGFR amplifications,35 but EGFR mutations as described in our series are uncommon outside of the newly recognized DMG-EGFR methylation-based subclass.36,37 These diffusely infiltrating (often bithalamic) pediatric diffuse midline gliomas show phenotypic similarities with GC. The gene discussed is EGFR; the disease is diffuse midline glioma.