MYB and low grade glioma: We also demonstrated that GC with low-grade features does not behave clinically like pediatric low-grade glioma (pedLGG) since the majority of children with LGC succumbed eventually to tumor progression, whereas pedLGGs are associated with low mortality in general.29,30 In molecular analyses, besides MYB/L-altered tumors, no pathognomic pedLGG alteration could be identified.