We also observed increases in FBXW7 mutations in CCNE1-amplified EG adenocarcinoma, with a significant increase in CCNE1-amplified EA (8.9% vs. 2.4%, P = 0.002) and modest albeit not statistically significant increase in CCNE1-amplified gastric adenocarcinoma (5% vs. 3.4%, P = 0.39; Fig. 2A; Supplementary Fig. S2). Here, CCNE1 is linked to Esophageal atresia.