Here we observed that TP53 mutations were significantly enriched in CCNE1-amplified gastric adenocarcinoma (87.0% vs. 54.6%, P = 3.2 × 1011) but only slightly increased in CCNE1-amplified EA (90.6% vs. 85.6%, P = 0.10; Supplementary Fig. S2A and S2C). Here, TP53 is linked to gastric adenocarcinoma.