CCNE1 and adenocarcinoma: We observed a significant decrease in MMR/MSI-H tumors in CCNE1-amplified adenocarcinoma (0.6% vs. 5.6%, P = 5.0 × 10−5), while there were no significant differences in TMB-high status (≥10 mt/Mb) between CCNE1-amplified and nonamplified tumors (Fig. 3A).