A dose-dependent cytolysis of B16F10-hB7H3 and B16F10-mB7H3 cells but not B16F10-WT cells was observed (Supplementary Fig. S5B), indicating that B7H3.mCAR T displayed specific and potent cytotoxic activity against both human and mouse B7-H3–expressing tumor cells. Here, CD276 is linked to neoplasm.