In contrast to WT NCI-N87 gastric cancer cell, knockout of B7-H3 in NCI-N87 tumor cells consistently abolished cytolysis and IFN production by B7H3.CAR EBVSTs (Supplementary Fig. S3E and S3F), showing that CAR-mediated killing and activation was dependent on B7-H3 expression. The gene discussed is CD276; the disease is gastric cancer.