While the lack of significant on-target off-tumor toxicity in B7H3.CAR T cells aligns with findings from other groups (48–50) and is reinforced by observations (3) including our own that underscore a lower abundance of B7-H3 in normal tissues compared with tumors, it may be prudent to conduct additional syngeneic safety studies in a larger cohort of mice. The gene discussed is CD276; the disease is neoplasm.