HTR3A and dysautonomia: We observed cisplatin-induced dysautonomia, characterized by increased sympathetictone and reduced vagal tone, a phenomenon that is related to GI disorders.Furthermore, cisplatin can induce changes in serotonin secretion by enterochromaffincells, which can be active 5-HT3 and 5-HT4 receptors, inducingrelaxation of gastric muscles and gastric dysmotility (1).