NFKB1 and obesity due to melanocortin 4 receptor deficiency: To clarify the question of whether the direction of the relationship for HbA1c and NF-κB is due to obesity or obesity caused by these factors, and to show whether MUC1 has a role in these links, it was determined that all three genes were upregulated in obesity and were statistically significant between groups (p<0.05).