There was no observed prognostic association of ZNF331 promoter methylation status with DFS, when adjusting for other predictors of patient survival, including age, sex, performance status, tumour site, stage, node status, histologic grade, and CIMP status using multivariable Cox regression analysis (p = 0.28) (Figure 2(b)). The gene discussed is ZNF331; the disease is neoplasm.