LEPROT and obesity due to melanocortin 4 receptor deficiency: In humans, GEO2R analysis of the Gene Expression Omnibus (GEO) GSE2508 (GPL92) data set from the study performed by Lee et al. (28) shows that adipocytes isolated from male and female Pima Indian patients with severe obesity (BMI = 55 ± 8; n = 19) are characterized by increased inflammation and a higher level of LEPROT mRNA compared with nonobese controls (BMI = 25 ± 3; n = 20), confirming the association between LEPROT expression and human obesity at the level of adipocytes (log [fold change] = 0.432; P = 4.67 × 10–5; Supplemental Figure 10A).