MAPK8 and obesity due to melanocortin 4 receptor deficiency: Consistent with a decrease in systemic inflammation in Endo1-KO mice, Endo1 deletion is associated with a significant decrease in JNK phosphorylation in the hypothalamus and liver and is associated with no significant changes of p-JNK in the adipose tissue (Figure 4C), suggesting an overall reduction in obesity-related central and peripheral inflammation in Endo1-KO mice.