Among those were several CDGs known to be involved in PDA, including MYC, CCND1, SRC, AKT1, JUN, CTNNB1, EGFR, CREB1, MDM2, and those encoding heat shock proteins (HSPs) (24–27), which is consistent with findings from experimental circadian models of carcinogenesis in PDA (28). This evidence concerns the gene CREB1 and Patent ductus arteriosus.