However,disambiguation of these TFs has been difficult to achieve to a large extent because invasivetumor cells adapt in complex ways to motility, adhesiveness, hypoxia, metabolism, and immuneresponses within their microenvironments [37].Currently, in addition to the classical TFs involved in GBM, including SOX2, OCT4, NANOG,KLF4, c-MYC, β-catenin, STAT3, NF-κB, HIF-1α and YAP/TAZ [ 38– 40] , there are also numerous otherGSC-related TFs ( Table 2). The gene discussed is HIF1A; the disease is glioblastoma.