CHI3L1 and glioblastoma: Furthermore, the protein Chi3l1,which is prevalent in GBM, influences the GSC state by engaging with CD44, triggering acascade involving β-catenin, Akt, and STAT3, propelling GSCs toward a mesenchymalphenotype and indicating the critical influence of β-catenin on GSC plasticity and tumorprogression [135].