TFs are expressed at relatively high levels in GSCs,maintaining the perpetual self-renewal of GBM cells [24].Typically, NSCs in the SVZ do not express IDH1, but certain NSCs carrying low-frequencymutations in IDH1 and TP53 can migrate outward, eventually progressing to tumor sitesdistant from the SVZ. Here, IDH1 is linked to glioblastoma.