After manipulating the expression of 5‐HT receptors in APP/PS1 mice, c‐Fos+ cells were also restored to normal conditions (Figure 5e,f), which suggests that 5‐HT1AR and 5‐HT2AR serve as major mediators for amygdala hyperactivity in AD course from early neuropathology to the advanced phase. Here, FOS is linked to Alzheimer disease.