A study found that the Shenfu injection can reduce the levels of plasma IL-10 and NT-pro BNP in patients with HF, and increase the proportion of TGF-β1, peripheral blood CD4+, and CD4+CD+25Foxp3+Treg cells, thereby exerting an immune regulatory role and then delaying the development of HF (139). This evidence concerns the gene NPPB and hydrops fetalis.