In addition, in animal experiments, the Qiliqiangxin capsule can improve the serum concentrations of VEGF and HIF-1 in HF rats, and activate the angiogenesis pathway associated with HIF-1-VEGF, thereby promoting angiogenesis, alleviating myocardial ischemia and hypoxia injury, and delaying ventricular remodeling. This evidence concerns the gene VEGFA and hydrops fetalis.