Experimental studies have proved that the Shenfuqiangxin mixture can upregulate the expression of phosphorylated AMPK (p-AMPK) and PGC-1α in rats with HF, reduce the levels of serum BNP, free fatty acid (FFA) and LDH in HF rats, regulate glucose transport and fatty acid oxidation metabolism, and accelerate myocardial energy metabolism (133). This evidence concerns the gene NPPB and hydrops fetalis.