- The pain and temperature sensitivities of diabetic mice were improved- Nrf2 expression was increased in the diabetic peripheral nerves, and NF-KB pathway inhibition protected nerves upon RSV treatment in peripheral neuropathy- RSV modulated the anti-inflammatory microenvironment of peripheral nerves by increasing Nrf2 activation and p-p65 expression. The gene discussed is NFKB1; the disease is peripheral neuropathy.