Park et al. indicated that RSV elevated adiponectin receptor-1 (AdipoR1) and AdipoR2 expression and activated the AMPK-SIRT1-peroxisome proliferator-activated receptor (PPAR)-gamma coactivator (PGC)-1alpha axis, and peroxisome PPAR-alpha, thus reduced lipotoxicity and improved OS, cell apoptosis, and endothelial dysfunction in DN (59). This evidence concerns the gene SIRT1 and liver dysplastic nodule.