- RSV decreased the expression of p65 and IκB-α in treated rats- Ameliorated the elevated levels of TNF-α, IL-6, and COX-2- RSV decreased in nerve MDA levels- NF-κB inhibitory activity and anti-inflammatory activity of RSV contribute to neuroprotection in diabetic neuropathy. The gene discussed is PTGS2; the disease is diabetic neuropathy.