VEGFA and neoplasm: Many tumor cells express high levels of VEGFA and its receptors/co-receptors (Lalla et al., 2003; Donnem et al., 2009; Capp et al., 2010; Goel and Mercurio, 2013; Nordby et al., 2015; Morimoto et al., 2019); thus, bevacizumab can theoretically exert direct cytotoxic effects on these cells by blocking VEGFA.