Sheth (2023) revealed the upregulation of immunity genes, including TEPs and complement-like system components, in both midguts and carcasses upon Wolbachia infection. TEPs (TEP1, TEP3, and TEP14) have their impact on P. falciparum infection. TEP1 may play a role in An. stephensi’s anti-Plasmodium defense, shedding light on Anopheles-Wolbachia-Plasmodium interactions and their potential for Wolbachia-based malaria control. Here, TEP1 is linked to malaria.