the Diary booklets which include:-the Daily Symptom Report (DSR), a checklist-the State scale of the State-Trait Anxiety Inventory (STAIS), BDI, Aggression Questionnaire (BPAQ) and Barratt Impulsiveness Scale version 11 (BIS-11)Biochemical Measures: the hormone (estradiol, progesterone, testosterone, LH, FSH and prolactin) and cytokine (IL-1b, IL-6, IL-8, IFNg and TNFa). The gene discussed is BRD2; the disease is Anxiety.