Immunohistochemistry (IHC) analysis in esophageal squamous cell carcinoma (ESCC) and primary cutaneous melanoma (PCM) revealed LAMP-3+ DCs infiltrating the peritumoral area and aggregating around CD8+ and CD25+, and OX40+ T cells, respectively (67, 68). The gene discussed is TNFRSF4; the disease is esophageal squamous cell carcinoma.