NFKB1 and Sepsis: Additionally, the Arg-304-His substitution, which is induced by the rs2230349 G-to-A mutation in G protein-coupled receptor kinase 5, has been shown to disrupt the function of G protein-coupled receptor kinase 5 and reduce the IκB-α/nuclear factor (NF)-κB-mediated inflammatory response, ultimately providing genetic protection against sepsis progression and susceptibility to mortality [69].