SRPK1 overexpression can promote cell proliferation, inhibit apoptosis in primary human pulmonary microvascular endothelial cells, and alleviate sepsis-induced ALI in vivo through forkhead box O 3-mediated transcriptional inactivation of NLRP3 and inhibition of NLRP3 mRNA and protein expression. Here, SRPK1 is linked to acute respiratory distress syndrome.