ROC: Receiver operating characteristic; AUC: Area under the curve; MST: Median survival time; CI: Confidence interval; HR: Hazard ratio; PS: Performance status; CA 19-9: Carbohydrate antigen 19-9; CEA: Carcinoembryonic antigen; GTV: Gross tumor volume; BED10: Biological effective dose using the linear-quadratic model with α/β = 10 Gy; PBT: Proton beam radiotherapy.*According to the Eastern Cooperative Oncology Group. This evidence concerns the gene CEACAM5 and neoplasm.