Wnt/planar cell polarity (PCP) (VanderVorst et al., 2019), notch-jagged signaling (Cheung et al., 2016), and hypoxia-inducible factor 1 alpha (HIF-1α) signaling (Lehmann et al., 2017) are some defined key signaling pathways that can mediate collective-cell migration during cancer metastasis. This evidence concerns the gene HIF1A and cancer.