Plasticity of cancer cell migration also can be observed as a mesenchymal–amoeboid and amoeboid–mesenchymal through a balance between Rac and Rho signaling and surface protease activity (Wolf et al., 2007; Friedl and Wolf, 2010; Orgaz et al., 2014; Tognoli et al., 2021) and epithelial–amoeboid transition (Choi et al., 2016) targeting RHO/ROCK signaling pathways (Figure 1C). The gene discussed is RHO; the disease is cancer.