The tumor-associated endothelial cells also play a part in TME regulation by secreting TGF-β1, periostin, and epoxy eicosanoids to help cancer cells escape from dormancy (Panigrahy et al., 2012; Ghajar et al., 2013) along with vascular endothelial growth factor (VEGF) and CXCR7 to confer tumors with aggressive and lethal properties (Maishi and Hida, 2017). This evidence concerns the gene VEGFA and cancer.