TGFB1 and neoplasm: The tumor-associated endothelial cells also play a part in TME regulation by secreting TGF-β1, periostin, and epoxy eicosanoids to help cancer cells escape from dormancy (Panigrahy et al., 2012; Ghajar et al., 2013) along with vascular endothelial growth factor (VEGF) and CXCR7 to confer tumors with aggressive and lethal properties (Maishi and Hida, 2017).