Our study confirmed previous evidence indicating associations between the genetic variants MARK3 (rs11623869), PLCB4 (rs6086746), and GEMIN2 (rs2277458) with osteoporosis and serum 25OHD levels in a European-descent population and a southern Chinese cohort also associated with an admixed population such as the Mexican-Mestizo. Here, GEMIN2 is linked to osteoporosis.