Furthermore, due to ischemic conditions, ABCC5 protein levels were upregulated in ventricular samples from patients with end-stage heart failure.ABCC5 polymorphisms have been associated with T2DM, insulin resistance, and visceral fat accumulation, indicating its potential role in damaging endothelial cells through lipid metabolic pathways (27). The gene discussed is ABCC5; the disease is type 2 diabetes mellitus.