The insulin resistance (IR) or impaired insulin sensitivity is considered to be one of the major invisible changes, between 10 and 15 years, before the diagnosis and progression of different non-communicable diseases (NCDs), including type 2 diabetes (T2DM), nonalcoholic fatty liver disease (NAFLD), heart disease, and stroke (3–5). The gene discussed is INS; the disease is metabolic dysfunction-associated steatotic liver disease.