CEACAM5 and colonic neoplasm: ColoNode, which combines analysis of mRNAs of CEA (CEACAM5), Kallikrein Related Peptidase 6 (KLK6), Solute Carrier Family 35 Member D3 (SLC35D3), Mucin 2 (MUC2) and Periostin (POSTN) of half the LN volume is a successful colon cancer (CC) prognostic test that surpasses histopathology in identifying patients that will relapse and in addition grades patients with different degrees of risk (6).