ColoNode, which combines analysis of mRNAs of CEA (CEACAM5), Kallikrein Related Peptidase 6 (KLK6), Solute Carrier Family 35 Member D3 (SLC35D3), Mucin 2 (MUC2) and Periostin (POSTN) of half the LN volume is a successful colon cancer (CC) prognostic test that surpasses histopathology in identifying patients that will relapse and in addition grades patients with different degrees of risk (6). The gene discussed is SLC35D3; the disease is malignant colon neoplasm.