This supposition is supported by one study of non-CNS cancer patients demonstrating cognitive impairment that was correlated with pro-inflammatory plasma biomarkers including interferon-gamma (INF-Υ), interleukin one beta (IL-1β), interleukin two (IL-2) and fibroblast growth factor two (FGF2) (57). This evidence concerns the gene IL1B and Cognitive impairment.