TLR4 and periodontal disorder: Present in the oral cavity, where it causes periodontal disease, Fusobacterium nucleatum induces overexpression of TLR4 and BIRC3 (Baculoviral IAP Repeat Containing 3), activates the TLR4-MYD88d and ULK1/ATG7 autophagy network signaling pathways, and genomic loss of miR-18a* and miR-4802, favoring the acquisition of resistance to 5-fluorouracil treatment in people with colorectal cancer (89).