Also, in preclinically tested animal models, attenuated Salmonella typhimurium genetically modified to produce CCL21 induces intratumoral increases in IFN-γ, CXCL9 and CXCL10 levels and tumor reduction in a CD4+ and CD8+ expressing lymphocyte-dependent manner, providing safety in use (32). The gene discussed is CD8A; the disease is neoplasm.