TNF and colorectal cancer: Another study conducted on the FOLFOX chemotherapy regimen (comprising 5-FU, leucovorin calcium, and oxaliplatin) in a colorectal cancer model revealed that certain microbiome compositions can trigger the activation of nuclear transcription factor-κB (NF-κB) and enhance the production of interleukin-6 (IL-6) and tumor necrosis factor (TNF).