Among the modified or attenuated oncolytic adenoviruses, ONYX-015, with deletion of the 55kD E1B gene (48), OBP-301 (Telomelysin), with insertion of the promoter for hTERT (human telomerase reverse transcriptase), are being tested for replication in tumor cells, which overexpress hTERT (49), VCN-01, with tropism for RB-deficient tumor cells (Retinoblastoma) (50), and CAdVEC, a binary vector, derived from an oncolytic adenovirus and a helper-dependent adenovirus and with integrated genes for IL12 and PDL1 (CAdVECIL12_PDL1) and HER2 (human epidermal growth factor receptor 2) (51). Here, CD274 is linked to retinoblastoma.