Among the microorganisms that contribute to oxaliplatin efficacy are Bacteroides fragilis, which stimulates infiltration of CD8+ cytotoxic T lymphocytes into the tumor microenvironment (61), and microorganisms of the genera Ruminococcus, Clostridium (Clostridium butyricum), Eubacterium (Eubacterium hallii and Eubacterium rectale), Coprococcus, Faecalibacterium, Butyrivibrio etc., which produce butyric acid (62). Here, CD8A is linked to neoplasm.