Among the herpesvirus-based vectors tested are HF10, which can induce tumor necrosis in a CD8+ T lymphocyte-dependent manner and the release of several cytokines including IL2, IL12, TNF alfa, IFN alpha, IFN beta and IFN gamma (52), and ONCR-177, derived from HSV1, containing genes for IL12, CCL4, for PD1 and CTLA4 antagonists and the sequence for the extracellular domain of FLT3LG and inducing T lymphocyte and NK cell activation, and dendritic cell expansion and recruitment (53). This evidence concerns the gene CTLA4 and neoplasm.