The SLICC criteria include clinical (malar or discoid eruption, photosensitivity, oral ulcers, non-scarring alopecia), biological (anemia, lymphopenia, thrombocytopenia, leukocytosis, low complement C3 and C4 fractions, antiphospholipid antibodies, ANA, anti-double-stranded deoxyribonucleic acid antibodies [anti-dsDNA] and anti- anti-Smith (SM) positive) and systemic manifestations (arthritis, serositis, renal/neurological lesions) (19). The gene discussed is C4A; the disease is anemia (phenotype).