Additionally, changes in many immunological signals were found including the nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB), Janus kinase/signal transduction (JAK-STAT), signal transducer and activator of transcription 3 (STAT3), evoplaking (EVPL), transforming growth factor beta (TGFbeta) signaling, and IL2Rαs of which several have been confirmed to be implicated in vitiligo (9, 16, 33). The gene discussed is STAT3; the disease is vitiligo.