Additionally, changes in many immunological signals were found including the nuclear factor kappa-light-chain-enhancer of activated B cells (NFkB), Janus kinase/signal transduction (JAK-STAT), signal transducer and activator of transcription 3 (STAT3), evoplaking (EVPL), transforming growth factor beta (TGFbeta) signaling, and IL2Rαs of which several have been confirmed to be implicated in vitiligo (9, 16, 33). This evidence concerns the gene TGFB1 and vitiligo.